DNA Biopharm
The Finest Herbal Remedies.
Neuro-Fast Capsules contain the following:
Alpha Lipoic Acid.
In several studies, alpha-lipoic acid appears to help lower blood sugar levels. Its ability to kill free radicals may help people with diabetic peripheral neuropathy, who have pain, burning, itching, tingling, and numbness in arms and legs from nerve damage. Alpha-lipoic acid has been used for years to treat peripheral neuropathy in Germany. Taking alpha-lipoic acid may help another diabetes-related condition called autonomic neuropathy, which affects the nerves to internal organs. One study found that 73 people with cardiac autonomic neuropathy, which affects the heart, showed fewer signs of the condition when taking alpha-lipoic acid orally compared to placebo.
ALA is a very important micro-nutrient with diverse pharmacologic and antioxidant properties. Pharmacologically, ALA improves glycemic control and polyneuropathies associated with diabetes mellitus; it also effectively mitigates toxicities associated with heavy metal poisoning. As an antioxidant, ALA directly terminates free radicals, chelates transition metal ions, increases cytosolic glutathione and vitamin C levels. Particular attention is paid to the potential benefits of ALA with respect to glycemic control, improved insulin sensitivity, oxidative stress, and neuropathy in diabetic patients. It appears that the major benefit of LA supplementation is in patients with diabetic neuropathy. (Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California 95817, USA.)
Coenzyme Q10
Coenzyme Q10 (CoQ10) is a substance that’s found naturally in the body and helps convert food into energy. CoQ10 is found in almost every cell in the body, and it is a powerful antioxidant.
Antioxidants fight damaging particles in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death. Scientists believe free radicals contribute to the aging process, as well as a number of health problems, including heart disease and cancer. Antioxidants, such as CoQ10, can neutralize free radicals and may reduce or even help prevent some of the damage they cause.
Some researchers believe that CoQ10 may help with heart-related conditions, because it can improve energy production in cells, prevent blood clot formation, and act as an antioxidant.
CoQ10 benefits peripheral nerves as well. People with diabetes often succumb to painful diabetic neuropathy and decreased ability to sense pressure, which can lead to disastrous injuries. Studies of diabetic patients with neuropathy show that CoQ10 improved nerve conduction velocity and strength of nerve impulses.
The study concluded that, "CoQ10 administration may represent a low-risk, high-reward strategy for preventing or treating diabetic neuropathy."
Acetyl-L-carnitine (ALC) is potentially effective at preventing peripheral neuropathy as well as lessening neuropathic symptoms once they have developed. Clinical trials consistently demonstrate the neuroprotective and antinociceptive effects of ALC. In addition, ALC is well tolerated without significant risk of side effects or drug-nutrient interactions.
Acetyl-L-carnitine (ALC) is a naturally occurring amino acid derivative that has both neuroprotective and antinociceptive effects. The mechanisms of action of ALC are not clear and are likely to be multifactorial, with effects on circulating neurotrophins, mitochondrial function (including anti-apoptotic effects), and synaptic transmission influencing both nerve structure/ function and patient perception of neuropathic symptoms. Clinical trials of several prominent causes of peripheral neuropathy suggest that ALC is effective for relief in a majority of patients. Electrophysiological testing and skin biopsies substantiate the regenerative capacity of ALC on nerve innervation. Some studies suggest that the regenerative capacity of ALC continues for up to 24 months after beginning therapy. Tolerance to ALC appears to be excellent with mild, infrequent side effects, including insomnia and gastric irritation. Given the level of evidence of ALC’s therapeutic effects on various types of PN combined with its lack of toxicity, ALC has the potential to dramatically affect the quality of life of patients with PN.
On top of its cancer and Alzheimer’s fighting properties, this compound is a potent pain reliever. It could even keep nerve pain from striking. Researchers have figured out one way it works to decrease nerve pain. It acts on certain markers of inflammation. Reducing these markers reduces pain.
Curcumin is a superstar when it comes to fighting inflammation. Thousands of studies have shown that it can lower inflammation in more than 97 mechanisms in the body.
This most recent study echoes the results of several others. One showed a decrease in inflammation markers and pain in four weeks. The researchers said that the supplement can be used as a treatment for diabetic neuropathy.
Another study showed that it helps improve the blood-sugar-lowering effect of insulin. This can protect against onset of nerve pain. Why? One of the risk factors is poor blood sugar control.
In one study, the supplement improved the function of the lining of the blood vessels. It also reduced markers of oxidative stress and inflammation. Its effects were comparable to those of a common drug used for neuropathy. But unlike most drugs, there aren’t any serious dangers. In human studies, side effects have mostly related to stomach upset.
Palmitoylethanolamide (PEA)
The history of PEA as a natural food ingredient with medicinal properties was first identified in 1943 as part of an epidemiological study focused on childhood rheumatic fever, which was noted to occur more frequently in those children who ate fewer eggs. Subsequently investigators noted that the occurrence of rheumatic fever was reduced in children fed egg yolk powder. Subsequently PEA was first identified in the 1950s as being an active anti-inflammatory agent in chicken egg yolk.
How does PEA work with pain?
Neuroinflammation
A solid body of evidence growing over the last 5-10 years indicates that chronic pain is largely due to a process called neuroinflammation, a condition characterized by activation of a number of inflammatory cells within the peripheral and central nervous systems. Neuroinflammation is characterized by migration of immune cells into an area of injury which release inflammatory chemical products that lead to activation and maintenance of chronic pain. These inflammatory cells, mast cells and glial cells, are now targets for development of new medications for treating chronic pain. Evidence indicates that suppression of the activation of these cells may limit or abolish the evolution of acute to chronic pain and may also act to reduce chronic pain.
On the forefront of research into agents that may act on neuroinflammation is Palmitoylethanolamide (PEA) which has been reported to reduce mast cell activation and to control glial cell behaviours. What is particularly exciting about PEA is that it is a naturally occurring agent produced by the body that has no reported serious side effects or drug-drug interactions, making it an extraordinarily safe treatment option. Over the last few years, especially in Europe and the Netherlands, more and more clinical research and practical experience have confirmed that PEA is an effective treatment option for chronic pain.
PEA is widely distributed in different body tissues, including the nervous system, and is synthesized on demand following stress, injury and/or pain and accumulates in affected tissues with inflammation. PEA serves to reduce inflammation and pain in different chronic pain conditions.
Most of the research on PEA has focused on neuropathic (nerve) pain where significant benefits have been identified. But there is a growing body of research indicating that PEA benefits many types of pain besides neuropathic pain which, incidentally, may also be due to the growing appreciation of the role of neuropathic pain in conditions such as arthritis and other inflammatory pain conditions as wel as visceral pain syndromes including endometriosis, interstitial cystitis and inflammatory bowel disease.
PEA also appears to possess effectiveness in syndromes associated with chronic pain including depression and anxiety.
Your nerves are covered by a special material called myelin sheath. It’s like insulation around electrical wires. When the myelin sheath is strong and intact, the electrical signals rushing from cell to cell move quickly, like open lanes on the freeway. Your body moves and behaves as it should. But when the myelin sheath is weakened and ripping apart, electrical signals get jumbled up along the way. It’s like hitting roadblocks on the freeway.
Your brain gets jumbled messages and your fingers and toes don’t respond as they should.
Neuro-Fast Capsules help repair myelin sheath damage. It helps form the sheath and the precious nerve fibers inside.
Resveratrol is a unique phytonutrient that is found in grapes, cranberries, blueberries, peanuts, and a wide range of other non-food plants including flowers and trees. Resveratrol clearly functions in the body as an antioxidant nutrient, and it also may have an important role to play as a phytoestrogen. Studies have shown that Resveratrol promotes an increase in mitochondrial function, which translates into an increase in energy expenditure, improved aerobic capacity, and enhanced sensorimotor function.
Resveratrol’s powerful antioxidant and anti-inflammatory properties have been shown to help relieve the pain associated with neuropathy, and may even be able to reverse some of the nerve damage.
AMLA - Indian Gooseberry
Amla’s anti-inflammatory properties have shown potential in reducing neuroinflammation, which, in turn, may help protect neurons and support overall neurological health. By modulating inflammatory pathways, amla may offer a promising approach in combating inflammation-related neurological challenges. By scavenging free radicals and reducing oxidative damage, the antioxidants in amla help maintain overall brain health and may potentially mitigate the onset or progression of neurodegenerative conditions.
The major findings of various studies proved that amla extract not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative stress.
