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Magnesium L-Threonate is the only form of magnesium that crosses the blood-brain barrier.

Magnesium is the fourth most abundant mineral in the body. It’s involved in over 300 metabolic reactions that are essential for human health, including energy production, regulation of blood pressure, nerve signal transmission, and muscle contraction. 


Low levels of magnesium are linked to a variety of illnesses such as type 2 diabetes, heart disease, mood disorders, and migraines.

Although magnesium is present in many whole foods like green leafy vegetables, legumes and nuts, up to two-thirds of people in the Western world don’t get enough magnesium that the body requires to function.

Many people take magnesium supplements to increase their magnesium intake but there are so many forms of magnesium available that it can be difficult to decide which one to take. 


Here is a short description of the various forms of magnesium available, as well as their uses.

Magnesium L-threonate is easily absorbed, can cross the blood-brain barrier and supports brain health, potentially aiding the treatment of disorders like depression and memory loss.

Magnesium citrate is one of the most popular types of magnesium supplements and easily absorbed by the body but does not cross the blood-brain barrier. It’s mainly used to raise magnesium levels and treat constipation.

Magnesium oxide is often used to relieve digestive complaints like heartburn and constipation. The body doesn’t absorb it well, so it isn’t a good choice for those who need to raise their magnesium levels.

Magnesium chloride is easily absorbed orally and used to treat heartburn, constipation, and low magnesium levels. Applying it topically may help relieve muscle soreness but it will not boost your magnesium levels.

Magnesium lactate is effective as a dietary supplement and possibly gentler on your digestive system. 

Magnesium malate is easily absorbed and may have less of a laxative effect than other forms. 

Magnesium taurate is used for managing high blood sugar and high blood pressure.

Magnesium sulphate, or Epsom salt, is frequently dissolved in water to treat stress and sore muscles. 

Magnesium glycinate is often used for its calming effects to treat anxiety, depression, and insomnia. 

Magnesium orotate may bolster heart health by improving energy production in your heart and blood vessel tissue.

Magnesium L- Threonate is a supplemental form of the essential trace mineral magnesium. This form offers a variety of potential benefits for health and longevity. It also plays important roles in bone health and development, cellular energy production, muscular contraction, and the development and optimal function of the nervous system and brain.

Magnesium threonate (also known as magnesium L-threonate) is considered to be one of the most bio-available and readily absorbed forms of magnesium for human consumption.

In the brain, magnesium threonate inhibits the stimulation of specific neurotransmitters by attaching to neural receptors that promote deeper relaxation. Additionally, the supplement may also play a role in inhibiting the secretion of cortisol and other stress hormones, helping to regulate the nervous system and alleviate anxiety.

Effects on Bone Metabolism

Magnesium L-Threonate has been investigated for its usage in bone health. It has been implicated as working synergistically with calcium in the production of collagen and mineralized nodules and augments the uptake of ascorbic acid into fibroblasts. Magnesium L-Threonate can also act on osteoclasts in an anti-osteoporotic manner.


Magnesium L-Threonate Powers the Brain

Learning is the process by which the brain is able to store new information by forming new connections between neurons in what are called networks. This process is an example of neuroplasticity. This process depends on the actual formation of these connections, as well as the number of connections that are available. We do know that when synapses, the connections that allow one nerve cell to communicate with the next, are diminished, memory impairment ensues. It is thought that this loss of synapses is an explanation for what is called “age dependent memory decline.”

Synapse formation is dependant upon a variety of factors that have been well studied including insulin, ghrelin, various trophic hormones and the ion magnesium, which enhances the activity of more than 300 enzymes.

It has now been discovered that magnesium is a critical player in the activation of nerve channels that are involved in synaptic plasticity. That means that magnesium is critical for the physiological events that are fundamental to the processes of learning and memory.

Magnesium L-Threonate, has the unique ability to permeate the brain and enhance the receptors that are involved in this process.

As reported in the journal Neuron, researchers demonstrated actual enhancement in the learning abilities, working memory, as well as short and long-term memory and even quality of sleep to people who were given Magnesium L-Threonate.

Researchers at MIT have demonstrated actual restoration of function in aging neurons. It appears that this specific form of magnesium may in fact be the only form of magnesium that significantly increases the levels of magnesium within the brain.

Magnesium l-Threonate readily crosses the brain’s protective filter, the blood-brain barrier, to get into the brain where it is needed

Similar to all other blood vessels in the body, the brain’s blood vessels are lined with endothelial cells, which serve as an interface between circulating blood and the vessel wall. However, unlike other blood vessels in the body, the endothelial cells in the brain are tightly wedged together, creating  a network of blood vessels that allows the entry of essential nutrients while blocking other substances. Unfortunately, this barrier is so effective at protecting against the passage of foreign substances that it often prevents life-saving drugs from being able to repair the injured or diseased brain. Magnesium L-Threonate can pass through this barrier.


Most menopausal women have inadequate magnesium levels, putting them at greater risk of poor health.

Magnesium plays a vital role in health throughout all life stages. During menopause, it is important for keeping bones strong and preventing osteoporosis or weakening of bones. Approximately 10–30% of postmenopausal women experience osteoporosis, a gradual decline in bone density. Magnesium L-Threonate helps decrease the progression of osteoporosis and supports bone health.

Magnesium may also reduce unwanted side effects of menopause, such as difficulty sleeping and depression while supporting heart health. Up to 60% of menopausal women experience insomnia or difficulty sleeping. Compared with premenopausal women, those transitioning through menopause, known as perimenopause, report significantly higher rates of poor sleep — in particular, waking up throughout the night. Hot flushes, night sweats, anxiety, depression, and a decrease in melatonin and progesterone, two hormones that have sleep-promoting effects, appear to be the main causes of menopausal insomnia. Lack of sleep is connected to an array of coexisting conditions related to menopause, such as irritability, depression, stress, and weight gain. Magnesium L-Threonate may promote sleep by regulating your body’s circadian rhythms, known as the body’s natural clock, and increasing muscle relaxation.

Heart disease is the leading cause of death in postmenopausal women. Although menopause does not cause heart disease, postmenopausal women are at an increased risk of high blood pressure, triglycerides, and levels of LDL (bad) cholesterol due to factors like decreased levels of oestrogen, stress, age, and poor lifestyle habits. Lower levels of magnesium are linked to poor heart health. In one study in 3,713 postmenopausal women, high magnesium levels were associated with lower inflammatory markers related to heart disease, indicating better heart health. Magnesium L-Threonate helps control heart muscle contractions and nerve impulses, allowing for a healthy heartbeat. Considering that postmenopausal women are at a higher risk of low magnesium levels, it’s important for women to pay attention to this mineral to support their heart health.

Getting enough magnesium each day is important for your overall health and may reduce unwanted symptoms of menopause. DNA-MLT from DNA Biopharm contains Magnesium L-Threonate which is one of the most efficient forms of magnesium available. DNA-MLT Capsules can be used in conjunction with our Meno-Fast Capsules.

For more information on menopause and Meno-Fast Capsules, please click on the Meno-Fast button.

Each 400ml Vegi-Cap contains 400mg Magnesium L-Threonate. Contains no fillers or preservatives.

Why are optimal magnesium levels important in people with diabetes?

Diabetics have trouble retaining magnesium inside the body due to high levels of sugar in their blood The body tries to remove this sugar through excess urination. The magnesium gets washed out with the excess sugar in the urine. This leads to lower levels of magnesium which can lead to a whole lot of other complications.

The importance of magnesium for diabetics.

  • Magnesium helps muscle cells relax, so insulin resistance goes down. Cells allow more sugar in. Blood sugar goes down.

  • The heart is a muscle. Magnesium helps the heart relax and lowers risk of cardiac issues in diabetics.

  • When magnesium is sufficient, it prevents calcium deposition in the inner walls of blood vessels. This helps prevent hardening of arteries.

  • Magnesium is important for the production of energy. Diabetics often feel tired because proper energy production is an issue.

  • Magnesium helps convert excess of glucose in the blood into glycogen. This gets stored in the liver. Excess sugar is thus removed from the blood.

  • Diabetics often complain of feeling pins and needles or numbness in their hands and feet. If you have enough magnesium, it can help prevent damage to nerves, a condition called diabetic neuropathy.

To read more about diabetes and its treatment, please click on the Gluco-Fast button. If you have Neuropathy, click on the Neuro-Fast link.

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